Bariatric surgery in a patient with melanocortin 4 receptor mutation
نویسندگان
چکیده
منابع مشابه
Melanocortin-4 Receptor Mutations and Polymorphisms Do Not Affect Weight Loss after Bariatric Surgery
Bariatric surgery is the most effective long term weight-loss therapy for severe and morbidly obese patients. Melanocortin-4 Receptor (MC4R) mutations, the most frequent known cause of monogenic obesity, affect the regulation of energy homeostasis. The impact of such mutations on weight loss after bariatric surgery is still debated.The objective is to determine the impact of MC4R status on weig...
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Familial hypercholesterolemia (FH) is an autosomal co-dominant disorder of lipid metabolism, caused by mutations in LDL receptor gene. The penetrance of FH is almost 100%, meaning that half of the offspring of affected parents born with disease. The patients are at risk of premature coronary heart disease (CHD). There is no report about the molecular basis of FH in Iran. Identification of mutat...
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INTRODUCTION A BMI of over 35-45kg/m2 is deemed the upper limit for considering a patient for a renal transplant. Voluntary weight loss attempts are a major concern for patients while on hemodialysis, however, bariatric surgeries have opened up a new door to notable weight loss results, even demonstrating significant improvements of patients' diabetic profile and hypertension. CASE REPORT Cas...
متن کاملAnti-melanocortin-4 receptor autoantibodies in obesity.
BACKGROUND The melanocortin-4 receptor (MC4R) is part of an important pathway regulating energy balance. Here we report the existence of autoantibodies (autoAbs) against the MC4R in sera of obese patients. METHODS The autoAbs were detected after screening of 216 patients' sera by using direct and inhibition ELISA with an N-terminal sequence of the MC4R. Binding to the native MC4R was evaluate...
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279 A 27-year-old man presented for sleep evaluation prior to his bariatric surgery. He was obese (weight 310 lb, BMI 44.5 kg/m2), and he reported snoring and excessive daytime sleepiness; his wife witnessed apneas. A split-night polysomnogram was performed, which documented severe obstructive sleep apnea with an apnea-hypopnea index (AHI) of 44/h and a required positive airway pressure of 15 c...
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ژورنال
عنوان ژورنال: Endocrine Abstracts
سال: 2013
ISSN: 1479-6848
DOI: 10.1530/endoabs.31.p71